Mechanisms of Action and Change in Psychedelic-Assisted Therapies: A Holistic Framework for Ethical, Competent Clinical Care

Reason for Hope's Chief Science Officer, Lynnette A. Averill, Ph.D., and Logan Neitzke-Spruill, Ph.D. introduce a non-neuroreductionist, multilevel framework that distinguishes mechanisms of action from mechanisms of change, highlighting how neuroplasticity, memory updating, relational processes, contextual factors, and meaning-making may interact to support therapeutic change.

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